Hovenia dulcis, known as the oriental raisin tree, is mainly found in East Asia. It has long
been used as traditional folk remedies for alcohol intoxication.
7 Korean scientists have conducted research funded by the national library of medicine(
the American government) on the effects of Hovenia dulcis aka ( oriental raisins), and
what it does to reduce hangover symptoms.
Materials and methods: Twenty-six eligible male adults with heterozygous ALDH2
(23.7±0.3 years old) consumed 360mL of Korean Soju (50g alcohol) together with HDE
(Orientals raisins)(2460mg) or matched placebo with subsequent crossover. The blood
samples were taken at baseline and 1, 4, and 12h post-treatment.
Results: Blood alcohol, acetaldehyde, and total hangover scores were highest at 1h
post-treatment with no difference between groups, but declines in hangover symptom
scores were significant in the HDE group compared to the placebo group. Significant
differences between groups were also observed on interleukin (IL)-6, IL-10, IL-10/IL-6
ratio, and aspartate aminotransferase levels, but not on endotoxins. Pearson correlation
analysis revealed a positive correlation between total hangover symptom scores and
IL-6 and IL-10 level. Further analyses by CYP2E1 polymorphism at rs10776687,
rs2031920, rs3813867, and rs4838767 alleles showed a reversed association,
suggesting that CYP2E1 polymorphism might be an effect modifier.
Conclusions: The results suggest that a favorable effect of HDE on alcohol hangovers
might be associated with enhancing homeostatic regulation of inflammatory response.
The magnitude of impact might be different in the presence of CYP2E1 polymorphism.
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